Athletic Performance of Horses Previously Infected with R. equi Pneumonia as Foals
نویسندگان
چکیده
Rhodococcus equi infection produces an insidious disease in foals 1 to 4 months of age, with intrapulmonary and extrapulmonary abscessation and organ dysfunction as common sequelae. Although amenable to treatment, this foalhood pneumonia has an impact on later athletic performance that has remained controversial. Christley and Hodgson1 noted that <64% of their recovered hospital cases (n 5 11) raced at least once, whereas Lavoie et al.2 reported that only 23% of the R. equi affected foals survived and raced successfully. In both studies, earnings or performance records of cases were not detailed. In contrast, Bernard et al.3 found no significant difference in the average earnings between the R. equi affected horses and controls (siblings) or between the R. equi affected horses and the average earnings of North American cohorts. However, although this study and those cited earlier established that some recovered foals can successfully race, it remained unknown if the severity of the bacterial infection impacted negatively upon race performance. Thus a multicenter retrospective study was conducted to determine if physical examination parameters, laboratory data, or radiographic abnormalities were associated with (a) reduced survival; (b) a reduced ability to race at least once; or (c) reduced earnings or starts.
منابع مشابه
Immunoglobulin G subisotype responses of pneumonic and healthy, exposed foals and adult horses to Rhodococcus equi virulence-associated proteins.
Rhodococcus equi causes severe pyogranulomatous pneumonia in foals and in immunocompromised humans. Replication of virulent isolates within macrophages correlates with the presence of a large plasmid which encodes a family of seven virulence-associated proteins (VapA and VapC to VapH), whose functions are unknown. Although cell-mediated immunity is thought to be crucial in eliminating R. equi i...
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Rhodococcus equi is a facultative intracellular pathogen that causes pneumonia in foals but does not induce disease in adult horses. Virulence of R. equi depends on the presence of a large plasmid, which encodes a family of seven virulence-associated proteins (VapA and VapC to VapH). Eradication of R. equi from the lungs depends on gamma interferon (IFN-gamma) production by T lymphocytes. The o...
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Rhodococcus equi is a facultative intracellular pathogen that causes pneumonia in young foals but does not induce disease in immunocompetent adult horses. Clearance of R. equi depends mainly on gamma interferon (IFN-gamma) production by T lymphocytes, whereas the predominance of interleukin 4 (IL-4) is detrimental. Young foals, like neonates of many other species, are generally deficient in the...
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Rhodococcus equi is an opportunistic pathogen in immunocompromised humans and an important primary pathogen in young horses. Although R. equi infection can produce life-threatening pyogranulomatous pneumonia, most foals develop a protective immune response that lasts throughout life. The antigen targets of this protective response are currently unknown; however, Mycobacterium tuberculosis is a ...
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